TH-257
CAS No. : 2244678-29-1
| Size | Price | Stock |
|---|---|---|
| 5mg | $60 | In-stock |
| 10mg | $82 | In-stock |
| 25mg | $134 | In-stock |
| 50mg | $188 | In-stock |
| 100mg | $260 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-122630 |
| M.Wt: | 422.54 |
| Formula: | C24H26N2O3S |
| Purity: | >98 % |
| Solubility: | DMSO : 250 mg/mL (ultrasonic) |
TH-257 is a potent inhibitor of LIMK1 and LIMK2 with IC50 values of 84 nM and 39 nM for LIMK1 and LIMK2, respectively, and it can be used as a chemical probe for LIMK1 and LIMK2. TH-257 is an allosteric inhibitor targeting a binding pocket induced by an αC and DFG-out conformation. TH257 is exquisitely selective and no significant activity against the wider kinome has been observed in the KINOMEscan assay at 1 μM[1]. In Vitro:TH-257 exhibits good biochemical and cellular potencies. But its extremely rapid in vitro clearance renders it unsuitable as a potential in vivo tool[2].
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