NAMPT inhibitor-linker 1
CAS No. : 2241019-57-6
| Size | Price | Stock |
|---|---|---|
| 1mg | $280 | In-stock |
| 5mg | $700 | In-stock |
| 10mg | $1120 | In-stock |
| 25mg | $2240 | In-stock |
| 50mg | $3584 | In-stock |
| 100mg | $5734 | In-stock |
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| Cat. No. : | HY-112615 |
| M.Wt: | 668.71 |
| Formula: | C36H37FN6O6 |
| Purity: | >98 % |
| Solubility: | DMSO : 12.5 mg/mL (ultrasonic;warming;heat to 60°C) |
NAMPT inhibitor-linker 1 is a drug-linker conjugates for ADC, composed of an NAMPT inhibitor as a payload, and a linker. ADC-3 consists of an NAMPT inhibitor-linker 1 and an anti-c-Kit monoclonal antibody, exihibits potent activity against c-Kit expressing cell lines such as GIST-T1 and NCI-H526 cells, with IC50s of <3 pM and 9 pM, respectively. In Vitro:ADC-3 exihibits potent activity against c-Kit expressing cell lines such as GIST-T1 and NCI-H526, with IC50s of <3 pM and 9 pM, respectively[1]. In Vivo:ADC-3 (20 mg/kg, i.v. for 28 days) is tolerated, and causes tumor stasis in mice bearing GIST-T1 cells[1].
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