Monensin (sodium)
CAS No. : 22373-78-0
(Synonyms: Monensin A (sodium))
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| Cat. No. : | HY-N0150 |
| M.Wt: | 692.85 |
| Formula: | C36H61NaO11 |
| Purity: | >98 % |
| Solubility: | DMSO : 2 mg/mL (ultrasonic;warming;heat to 60°C);Ethanol : 20 mg/mL (ultrasonic) |
Monensin (Monensin A) sodium, an orally active antibiotic, is an ionophore that mediates Na+/H+ exchange. Monensin sodium is a potent Wnt signaling inhibitor. Monensin sodium causes a marked enlargement of the multivesicular bodies (MVBs) and regulates exosome secretion. Monensin sodium can be used for bacterial, fungal, and parasitic infections research, and shows anticancer effects[1][2][3][4].
IC50 & Target:bacterial[1]
In Vitro: Monensin (1-5 μM; 48 h) sodium results in a marked decrease in viability in a dose-dependent manner[1].
Monensin (1-5 μM; 24 h) sodium shows a statistically significant induction of apoptosis[1].
Monensin (0.1-1 μM; 24 h) sodium inhibits pEGFR and its downstream targets pAKT and pERK[1].
In Vivo: Monensin (10 mg/kg; po; daily; for 6 weeks) sodium suppresses progression of the intestinal tumors without any sign of toxicity on normal mucosa in multiple intestinal neoplasia (Min) mice[2].
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