Tubulin inhibitor 1
CAS No. : 2237054-53-2
| Size | Price | Stock |
|---|---|---|
| 5mg | $80 | In-stock |
| 10mg | $128 | In-stock |
| 25mg | $256 | In-stock |
| 50mg | $410 | In-stock |
| 100mg | $660 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-112607 |
| M.Wt: | 368.43 |
| Formula: | C21H24N2O4 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 125 mg/mL |
Tubulin inhibitor 1 is a tubulin inhibitor, inhibits tubulin polymerization. Tubulin inhibitor 1 shows potent anti-tumor activity, casues cellular mitotic arrest in the G2/M phase, and induces cellular apoptosis[1].
IC50 & Target: Tubulin[1]
In Vitro: Tubulin inhibitor 1 (Compound 7a3) is a tubulin inhibitor, inhibits tubulin polymerization[1].
Tubulin inhibitor 1 has potent anti-proliferative activity against SK-OV-3, MDA-MB-231, HeLa, A549, CT26 and MCF-7 cells, with IC50s of 16.7 ± 3.0, 31.4 ± 0.7, 32.8 ± 2.9, 67.0 ± 0.8, 58.0 ± 2.4 and 35.4 ± 5.6 nM, respectively[1].
Tubulin inhibitor 1 (40, 80, and 160 nM, 48 hours) markedly causes cellular mitotic arrest in the G2/M phase, induces apoptosis in SK-OV-3 cells[1].
In Vivo: Tubulin inhibitor 1 (50 mg/kg, i.p., every two days three times for 20-25 days) is well tolerated, significantly reduces tumour growth in Balb/c nude mice bearing SK-OV-3 cells[1].
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