Rupintrivir
CAS No. : 223537-30-2
(Synonyms: AG7088)
| Size | Price | Stock |
|---|---|---|
| 1mg | $175 | In-stock |
| 5mg | $320 | In-stock |
| 10mg | $510 | In-stock |
| 25mg | $890 | In-stock |
| 50mg | $1180 | In-stock |
| 100mg | $1590 | In-stock |
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| Cat. No. : | HY-106161 |
| M.Wt: | 598.66 |
| Formula: | C31H39FN4O7 |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (ultrasonic) |
Rupintrivirvr (AG7088), an antiviral drug, is a potent, selective and irreversible inhibitor of human rhinovirus (HRV) 3C protease. Rupintrivirvr inhibits replication of a panel of 48 different HRV serotypes in H1-HeLA and MRC-5 cell protection assays, with a mean EC50 of 0.023 μM. Rupintrivirvr shows immune-modulatory effect[1][2]. In Vitro: In H1-HeLa and MRC-5 cell protection assays, Rupintrivirvr (AG7088) inhibited the replication of all HRV serotypes (48 of 48) tested with a mean 50% effective concentration (EC50) of 0.023 μM (range, 0.003 to 0.081 μM) and a mean EC90 of 0.082 μM (range, 0.018 to 0.261 μM) as well as that of related picornaviruses including coxsackieviruses A21 and B3, enterovirus 70, and echovirus 11[1]. In Vivo: Rupintrivirvr (AG7088) reduces RV-induced TH-2 cytokine IL-4 in precision-cut lung slices (PCLS) of HDM-sensitized mice ex vivo[2].
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