IDH1 Inhibitor 1
CAS No. : 2234285-81-3
| Size | Price | Stock |
|---|---|---|
| 5mg | $780 | In-stock |
| 10mg | $1250 | In-stock |
| 25mg | $2580 | In-stock |
| 50mg | $3500 | In-stock |
| 100mg | $4780 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-112601 |
| M.Wt: | 450.39 |
| Formula: | C20H18F4N6O2 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 100 mg/mL |
IDH1 Inhibitor 1 is a potent, orally bioavailable, brain-penetrant and selective mutant IDH1 inhibitor with IC50s of 0.021 μM, 0.045 μM, and 2.52 μM for IDH1R132H, IDH1R132C, and IDH1WT, respectively[1]. Anticancer activity[1]. IC50 & Target: IC50: 0.021 μM (IDH1R132H), 0.045 μM (IDH1R132C), and 2.52 μM (IDH1WT)[1] In Vitro: IDH1 Inhibitor 1 (Compound 19) inhibits cellular HCT116-IDH1R132H/+ with an IC50 of 0.039 μM[1]. In Vivo: IDH1 Inhibitor 1 (Compound 19) inhibits 2-hydroxyglutarate (2-HG) production in a preclinical xenograft tumor model. IDH1 Inhibitor 1 is also profiled in a patient-derived IDH1 mutant HCT116-IDH1R132H/+ mechanistic xenograft tumor model in mice to evaluate in vivo inhibition of 2-HG production. IDH1 Inhibitor 1, dosed orally at 150 mg/kg, inhibits new 2-HG production[1].
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- IDH1 Inhibitor 1
- Cat. No.:
- HY-112601
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