JI051
CAS No. : 2234281-75-3
| Size | Price | Stock |
|---|---|---|
| 5mg | $220 | In-stock |
| 10mg | $320 | In-stock |
| 25mg | $590 | In-stock |
| 50mg | $950 | In-stock |
| 100mg | $1500 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
| We match the lowest price on market. | ||
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| Cat. No. : | HY-117113 |
| M.Wt: | 364.44 |
| Formula: | C22H24N2O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 125 mg/mL (ultrasonic) |
JI051 is a stabilizer for the Hes1-PHB2 interaction. JI051 interacts with a cancer-associated protein chaperone prohibitin 2 (PHB2), induces cell-cycle arrest by inhibiting the Notch downstream effector gene Hes1. Anti-cancer activity[1].
In Vitro: JI051 causes G2/M cell-cycle arrest[1].
JI051 (0.1-10 μM, 24 hours) significantly inhibits cell proliferation of HEK293 cells, with an EC50 of 0.3 μM[1].
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