FG-2216
CAS No. : 223387-75-5
(Synonyms: IOX3; YM311)
| Size | Price | Stock |
|---|---|---|
| 5mg | $40 | In-stock |
| 10mg | $64 | In-stock |
| 25mg | $128 | In-stock |
| 50mg | $190 | In-stock |
| 100mg | $280 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-15641 |
| M.Wt: | 280.66 |
| Formula: | C12H9ClN2O4 |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (ultrasonic) |
FG-2216 (IOX3) is a potent and orally active inhibitor of HIF prolyl hydroxylase-2 (PHD2), with an IC50 of 3.9 μM. FG-2216 induces robust erythropoietin and modest fetal hemoglobin in vivo[1][2][3].
IC50 & Target: IC50: 3.9 nM (PHD2)[1]
In Vitro: FG-2216 (50-100 μM; 24 h) stimulates erythropoietin (Epo) secretion by PHD2 inhibition in Hep3B cells[1].
FG-2216 (3-100 μM; 24 h) stabilizes HIF-1α and HIF-2α in Hep3B cells[1].
In Vivo: FG-2216 (40-60 mg/kg; p.o. twice a week for 150 d) induces erythropoiesis and a small elevation of hemoglobin (HbF) expression, and is well tolerated in rhesus macaques[2].
FG-2216 (50 mg/kg; p.o. once daily for 4 or 12 d) increases hematocrit, red blood cell counts, and hemoglobin levels in mice[1].
FG-2216 (40-60 mg/kg; a single p.o) reversibly induces endogenous Epo in rhesus macaques[2].
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