MB710
CAS No. : 2230044-57-0
| Size | Price | Stock |
|---|---|---|
| 5mg | $600 | In-stock |
| 10mg | $1050 | In-stock |
| 25mg | $2250 | In-stock |
| 50mg | $3600 | In-stock |
| 100 mg | Get quote | |
| 200 mg | Get quote | |
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| Cat. No. : | HY-120373 |
| M.Wt: | 457.29 |
| Formula: | C16H16IN3O3S |
| Purity: | >98 % |
| Solubility: | DMSO : 16.67 mg/mL (ultrasonic) |
MB710, an aminobenzothiazole derivative, is a stabilizer of oncogenic p53 mutation Y220C. MB710 binds tightly to the Y220C pocket and stabilizes p53-Y220C, with a Kd of 4.1?μM. MB710 shows anticancer activity in p53-Y220C cell lines[1].
IC50 & Target: Kd: 4?μM (p53-Y220C)
In Vitro: MB710 (0-200 μM; 72 hours) shows relatively low toxicity against all cell lines tested at concentrations up to 60?μM, while showing initial selective viability reduction at higher concentrations[1].
MB710 (72 hours) treats cancer cell lines NUGC3, NUGC4, WI38 and SW1088, with IC50s of 90, 120, >120, >120 μM, respectively[1].
MB710 (0-120 μM; 72 hours; HUH-7 cells) shows stronger cytotoxic effects in presence of p53-Y220C[1].
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