Finasteride (acetate)
CAS No. : 222989-99-3
(Synonyms: MK-906 (acetate))
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| Cat. No. : | HY-13635A |
| M.Wt: | 432.60 |
| Formula: | C25H40N2O4 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Finasteride (MK-906) acetate is a potent and competitive 5α-reductase inhibitor, with an IC50 of 4.2 nM for type II 5α-reductase. Finasteride acetate has approximately a 100-fold greater affinity for type II 5α-reductase enzyme than for the type I enzyme. Finasteride acetate can be used for the research of benign prostatic hyperplasia (BPH) and androgenic alopecia[1][2][3].
IC50 & Target: IC50: 4.2 nM (type II 5α-reductase)[1]
In Vitro: Finasteride (10 μM; 6-24 h) induces the expression of HO-1 and Nrf2 proteins in PC-3 cells[2].
Finasteride decreases the conversion of [3H]testosterone (T) to [3H]dihydrotestosterone (DHT) in P. crustosum[1].
In Vivo: Finasteride (0.1-0.5 mg/kg; p.o. once daily for 16 weeks) reduces prostatic size in dogs with BPH without adversely affecting semen quality or serum testosterone concentration[3].
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