SZL P1-41
CAS No. : 222716-34-9
| Size | Price | Stock |
|---|---|---|
| 5mg | $86 | In-stock |
| 10mg | $133 | In-stock |
| 25mg | $250 | In-stock |
| 50mg | $420 | In-stock |
| 100mg | $710 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-100237 |
| M.Wt: | 420.52 |
| Formula: | C24H24N2O3S |
| Purity: | >98 % |
| Solubility: | DMSO : 2.5 mg/mL (ultrasonic) |
SZL P1-41 is a specific Skp2 inhibitor, binds to the F-box domain of Skp2 to prevent Skp1 association and Skp2 SCF complex formation. SZL P1-41, like Skp2 deficiency, augments p27-mediated apoptosis/senescence, while it impairs Akt-driven glycolysis. Anti-tumor activities[1][2]. IC50 & Target: Skp2[1] In Vitro: SZL P1-41 (5-20μM; 24 hours) induces endogenous p27 protein expression in PC3 cells and also induced expression of p21, another Skp2 substrate[1]. In Vivo: SZL P1-41 (40-80 mg/kg; i.p.) displays a potent effect on inhibiting prostate and lung tumor growth in Nude mice bearing A549 and PC3 tumor xenografts[1].
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