Aurora inhibitor 1
CAS No. : 2227019-45-4
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| Cat. No. : | HY-111506 |
| M.Wt: | 459.57 |
| Formula: | C23H25N9S |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Aurora inhibitor 1 is a potent Aurora inhibitor with an IC50 of ≤ 4 nM and ≤13 nM for Aurora A and Aurora B kinase, respectively[1]. In Vitro: Aurora inhibitor 1 (Compound 16) exhibits Kd values of 0.01 nM for both Aurora A and Aurora B kinase[1]. In Vivo: Aurora inhibitor 1 (Compound 16) exhibits good drug exposure levels across species upon oral dosing, and shows excellent in vivo efficacy in a mouse xenograft tumor model when dosed orally[1].
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