Adoprazine


CAS No. : 222551-17-9

(Synonyms: SLV313)

222551-17-9
Price and Availability of CAS No. : 222551-17-9
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5mg $170 In-stock
10mg $280 In-stock
25mg $488 In-stock
50mg $780 In-stock
100mg $1050 In-stock
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Cat. No. : HY-14782
M.Wt: 405.46
Formula: C24H24FN3O2
Purity: >98 %
Solubility: DMSO : 50 mg/mL (ultrasonic)
Introduction of 222551-17-9 :

Adoprazine (SLV313) is a full 5-HT1A receptor agonist with a pEC50 of 9 at cloned h5-HT1A receptors. Adoprazine (SLV313) is a full D2 and D3 receptor antagonist with pA2s of 9.3 and 8.9 at hD2 and hD3 receptors, respectively. Adoprazine (SLV313) has the characteristics of atypical antipsychotics[1]. In Vitro:Adoprazine has high affinity at human recombinant D2, D3, D4, 5-HT2B, and 5-HT1A receptors, with pKis of 8.4, 8.4, 8.0, 7.9 and 9.1, respectively[1].
Adoprazine acts as a high potency dopamine D2 receptor antagonist and an efficacious serotonin 5-HT1A receptor agonist, with Emax value (% effect of 10 μM 5-HT) of 73 and pKB value of 8.5 [2]. In Vivo:Adoprazine (SLV313) (0.1-10 mg/kg; p.o.; single) is sufficient to reduce extracellular 5-HT and increase dopamine levels in the nucleus accumbens in a dose- and time-dependent manner[1].

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