Adoprazine (hydrochloride)
CAS No. : 222551-05-5
(Synonyms: SLV313 (hydrochloride))
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| Cat. No. : | HY-14782A |
| M.Wt: | 441.93 |
| Formula: | C24H25ClFN3O2 |
| Purity: | >98 % |
| Solubility: |
Adoprazine (SLV313) hydrochloride is a full 5-HT1A receptor agonist with a pEC50 of 9 at cloned h5-HT1A receptors. Adoprazine hydrochloride is a full D2 and D3 receptor antagonist with pA2s of 9.3 and 8.9 at hD2 and hD3 receptors, respectively. Adoprazine has the characteristics of atypical antipsychotics[1].
In Vitro:Adoprazine hydrochloride has high affinity at human recombinant D2, D3, D4, 5-HT2B, and 5-HT1A receptors, with pKis of 8.4, 8.4, 8.0, 7.9 and 9.1, respectively[1].
Adoprazine hydrochloride acts as a high potency dopamine D2 receptor antagonist and an efficacious serotonin 5-HT1A receptor agonist, with Emax value (% effect of 10 μM 5-HT) of 73 and pKB value of 8.5 [2].
In Vivo:Adoprazine (0.1-10 mg/kg; p.o.; single) hydrochloride is sufficient to reduce extracellular 5-HT and increase dopamine levels in the nucleus accumbens in a dose- and time-dependent manner[1].
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