Carbimazole
CAS No. : 22232-54-8
| Size | Price | Stock |
|---|---|---|
| 25g | $58 | In-stock |
| 100g | $215 | In-stock |
| 500g | $715 | In-stock |
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| Cat. No. : | HY-B0558 |
| M.Wt: | 186.23 |
| Formula: | C7H10N2O2S |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Carbimazole is an orally active antithyroid agent which rapidly converts to Methimazole after absorption and prevents thyroid peroxidase enzyme from iodinating and coupling the tyrosine residues on thyroglobulin, hence reducing the production of thyroxine. Carbimazole also displays anti-inflammatory and neuronal-protective activities, suggesting its application for hyperthyroidism and neurological research[1][2][3].
In Vitro: Carbimazole (0.01-2 mM, 6 h) inhibits the global translation of protein in SK-N-SH cells[1].
Carbimazole (0.5 mM, 12-72 h) inhibits hypoxic SK-N-SH cell injury and preserve intracellular ATP content in an oxygen-free atmosphere through inhibiting protein synthesis and activating MAPK[1].
In Vivo: Carbimazole (10, 15, 20 mg/animal/day, p.o., 21 d) shows mainly dose-dependent responses of basic physiological parameters in rabbits[2].
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