VU6007678
CAS No. : 2222737-15-5
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| Cat. No. : | HY-123778 |
| M.Wt: | 484.59 |
| Formula: | C25H29FN4O3S |
| Purity: | >98 % |
| Solubility: |
VU6007678 (compound 18g) is a central nervous system-penetrant muscarinic acetylcholine receptor(mAChR) potentiator. VU6007678 potentiates acetylcholine-mediated signaling at human M1, M3, M5 and rat M1, M3, M4, M5 muscarinic acetylcholine receptors. VU6007678 is applicable to research related to Alzheimer's disease, schizophrenia, and ischemic stroke[1].
In Vitro:VU6007678 (10-point serial dilutions starting at 30 μM; 2.5 min with cells, 1 min with EC20 acetylcholine) potently acts as a positive allosteric modulator of human M5 receptors expressed in CHO cells, with an EC50 of 41 nM and a maximum response of 74% of acetylcholine's peak activity[1].
VU6007678 (10-point serial dilutions starting at 30 μM; 2.5 min with cells, 1 min with EC20 acetylcholine) acts as a positive allosteric modulator of rat M5 receptors expressed in CHO cells, with an EC50 of 74 nM and a maximum response of 76% of acetylcholine's peak activity[1].
VU6007678 (10-point serial dilutions starting at 30 μM; 2.5 min with cells, 1 min with EC20 acetylcholine) acts as a positive allosteric modulator of human M1 receptors expressed in CHO cells, with an EC50 of 1034 nM and a maximum response of 67% of acetylcholine's peak activity[1].
VU6007678 (10-point serial dilutions starting at 30 μM; 2.5 min with cells, 1 min with EC20 acetylcholine) acts as a positive allosteric modulator of human M3 receptors expressed in CHO cells, with an EC50 of 466 nM and a maximum response of 71% of acetylcholine's peak activity[1].
VU6007678 (10-point serial dilutions starting at 30 μM; 2.5 min with cells, 1 min with EC20 acetylcholine) acts as a positive allosteric modulator of rat M1 receptors expressed in CHO cells, with an EC50 of 904 nM and a maximum response of 69% of acetylcholine's peak activity[1].
VU6007678 (10-point serial dilutions starting at 30 μM; 2.5 min with cells, 1 min with EC20 acetylcholine) acts as a positive allosteric modulator of rat M3 receptors expressed in CHO cells, with an EC50 of 772 nM and a maximum response of 51% of acetylcholine's peak activity[1].
VU6007678 (10-point serial dilutions starting at 30 μM; 2.5 min with cells, 1 min with EC20 acetylcholine) weakly acts as a positive allosteric modulator of rat M4 receptors expressed in CHO cells, with an EC50 of 3913 nM and a maximum response of 49% of acetylcholine's peak activity[1].
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