DNDI-8219
CAS No. : 2222660-40-2
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| Cat. No. : | HY-124623 |
| M.Wt: | 345.23 |
| Formula: | C13H10F3N3O5 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
DNDI-8219 (compound 58) is a potent selective and orally active trypanocidal agent, possessing inhibitory activity against Trypanosoma cruzi (T. cruzi) with an IC50 of 0.4 μM. DNDI-8219 has low cytotoxicity (L6 cells IC50 > 100 μM). DNDI-8219 can effectively cure chronic T. cruzi infection and markedly reduce parasite burdens in mouse model. DNDI-8219 has good solubility, metabolic stability and safety[1]. IC50 & Target: IC50: 0.4 μM (T. cruzi)[1] In Vivo: DNDI-8219 (50 or 100 mg/kg; PO; once daily for five days) completely cures chronic infection, as well as markedly reduces parasite burdens in mice[1].
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