ORIC-101
CAS No. : 2222344-98-9
| Size | Price | Stock |
|---|---|---|
| 1mg | $620 | In-stock |
| 5mg | $1850 | In-stock |
| 10mg | $3000 | In-stock |
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| 100 mg | Get quote | |
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| Cat. No. : | HY-112710 |
| M.Wt: | 501.74 |
| Formula: | C34H47NO2 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 100 mg/mL |
ORIC-101 is a highly potent and selective glucocorticoid receptor antagonist, with an EC50 of 5.6 nM. Anti-cancer activity. ORIC-101 is a click chemistry reagent, itcontains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
IC50 & Target: EC50: 5.6 nM (Glucocorticoid receptor)[1]
In Vitro: ORIC-101 shows markedly reduced androgen receptor agonism (EC50, 2500 nM) and CYP2C8 and CYP2C9 inhibition profiles (IC50, >10 μM)[1].
ORIC-101 (1-1000 nM) dose-dependently reduces the expression of n GR-mediated target gene (FKBP5 and GILZ), with IC50s of 17.2 and 21.2 nM, respectively[1].
In Vivo: ORIC-101 (75 mg/kg, P.O. twice a day for 16-22 days) enhances the anti-tumor activity in combination with gemcitabine and carboplatin in OVCAR5 xenograft tumor in cortisol-treated mice[1].
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