Naproxen
CAS No. : 22204-53-1
(Synonyms: (S)-Naproxen)
| Size | Price | Stock |
|---|---|---|
| 10g | $13 | In-stock |
| 25g | $18 | In-stock |
| 100g | $31 | In-stock |
| 500g | $120 | In-stock |
| 1000g | $202 | In-stock |
| > 2 kg | Get quote | |
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| Cat. No. : | HY-15030 |
| M.Wt: | 230.26 |
| Formula: | C14H14O3 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 100 mg/mL;H2O : 75 mg/mL (ultrasonic;warming) |
Naproxen is a COX-1 and COX-2 inhibitor with IC50s of 8.72 and 5.15 μM, respectively in cell assay. IC50 & Target: IC50: 8.72 μM (COX-1), 5.15 μM (COX-2)[1] In Vitro: Naproxen etemesil is a lipophilic, non-acidic, inactive prodrug of naproxen that is hydrolysed to pharmacologically active Naproxen once absorbed. Naproxen is a well known nonsteroidal anti-inflammatory drug. Naproxen is approximately equipotent inhibitor of COX-1 and COX-2 in intact cells with IC50s of 2.2 μg/mL and 1.3 μg/mL, respectively[1]. In Vivo: Naproxen exerts an anti-inflammatory and antifibrotic effect in mouse model of bleomycin-induced lung fibrosis. Naproxen also downregulates TGF-β levels and Smad3/4 complex formation[2]. Naproxen is shown to inhibit the time-courses of pain, fever and PGE2 with similar potencies (IC50=27, 40, 13 μM)[3].
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