GW8510
CAS No. : 222036-17-1
| Size | Price | Stock |
|---|---|---|
| 5mg | $120 | In-stock |
| 10mg | $200 | In-stock |
| 25mg | $400 | In-stock |
| 50mg | $650 | In-stock |
| 100mg | $1050 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-112358 |
| M.Wt: | 449.51 |
| Formula: | C21H15N5O3S2 |
| Purity: | >98 % |
| Solubility: | DMSO : 25 mg/mL (ultrasonic) |
GW8510 is a potent cyclin-dependent kinase-2 (CDK2) inhibitor. GW8510 is also a ribonucleotide reductase M2 (RRM2) inhibitor. GW8510 exhibits neuroprotective and anticancer activities[1][2][3].
In Vitro: GW8510 (0.5-4 μM; 72 h) inhibits viability of HCT116 cells in a dose-dependent manner[2].
GW8510 (1-4 μM; 24 h) inhibits RRM2 expression without alteration of RRM1 expression[2].
GW8510 inhibits CDK2 and other CDKs when tested in in vitro biochemical assays, when used on cultured neurons it only inhibits CDK5[1].
GW8510 inhibits the death of cerebellar granule neurons caused by switching them from high potassium medium to low potassium medium[1].
Combination with GW8510 (5 μM; 48 h) and Tamoxifen (5 μM; 48 h) significantly inhibits survival of the Tamoxifen-resistant breast cancer cells (BBCs) through induction of autophagic cell death[3].
In Vivo: Combination with GW8510 and Tamoxifen enhances tumoricidal effect on Tamoxifen-resistant BBC xenograft through autophagy induction[3].
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