MSC1094308
CAS No. : 2219320-08-6
| Size | Price | Stock |
|---|---|---|
| 5mg | $95 | In-stock |
| 10mg | $150 | In-stock |
| 25mg | $300 | In-stock |
| 50mg | $510 | In-stock |
| 100mg | $870 | In-stock |
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| Cat. No. : | HY-123872 |
| M.Wt: | 462.55 |
| Formula: | C29H29F3N2 |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (ultrasonic) |
MSC1094308 is a non-competitive and reversible VPS4B/p97 (VCP) (I/II type AAA ATPase) allosteric inhibitor, with IC50 values of 0.71 μM and 7.2 μM for VPS4B and p97, respectively[1]. MSC1094308 inhibits the D2 ATPase activity by binding to a drugable hotspot of p97. MSC1094308 can be used in study of cancer[1]. IC50 & Target: IC50: 0.71 μM (VPS4B), 7.2 μM (p97)[1]. In Vitro: MSC1094308 (10 µM; 8 h) induces accumulation of polyubiquitin as a biomarker for degradation inhibition in HCT116 cells[1].
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