RH1
CAS No. : 221635-42-3
(Synonyms: NSC 697726)
| Size | Price | Stock |
|---|---|---|
| 1mg | $240 | In-stock |
| 5mg | $540 | In-stock |
| 10mg | $870 | In-stock |
| 25mg | $1750 | In-stock |
| 50mg | $2800 | In-stock |
| 100 mg | Get quote | |
| 200 mg | Get quote | |
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| Cat. No. : | HY-13741 |
| M.Wt: | 234.25 |
| Formula: | C12H14N2O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 1.25 mg/mL (ultrasonic;warming;heat to 60°C) |
RH1 (NSC 697726) is a potent bioreductive agent with profound anti-cancer activity in vitro and in vivo. In Vitro:Treatment of NQ16 cells with RH1 (50 and 100 nM) for 60 and 120 min results in a significant increase (p< 0.05) in cross-linked DNA. RH1 induces apoptosis in a time- and concentration-dependent manner in NQ16 cells [1]. In Vivo:RH1 exhibits antitumor activity in a dose-dependent manner against NQ16 tumors growing in athymic mice. RH1 treatment (0.4 mg/kg and 0.2 mg/kg) of mice bearing NQ16 tumors results in a significant reduction in tumor volume between treated groups and controls as early as 5 days after the treatment period ended. Low-dose RH1 (0.1 mg/kg) also results in a significant reduction in tumor volume between treated mice and controls[2].
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