(2E)-OBAA
CAS No. : 221632-26-4
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| Cat. No. : | HY-101015 |
| M.Wt: | 428.66 |
| Formula: | C28H44O3 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
(2E)-OBAA is a potent phospholipase A2 (PLA2) inhibitor, with an IC50 of 70 nM. (2E)-OBAA induces apoptosis of HUVEC cells. (2E)-OBAA blocks Melittin-induced Ca2+ influx in Trypanosoma brucei, with an IC50 of 0.4 μM[1][2][3][4]. IC50 & Target:IC50: 70 nM (PLA2)[1] In Vitro: (2E)-OBAA (5.7 μM) induces apoptotic cell death of human umbilical vein endothelial cells (HUVEC). After 16 h of treatment, almost all of the cells has disintegrated into apoptotic bodies[1]. In Vivo: (2E)-OBAA (2.5-7 mg/kg, IV) significantly and dose-dependently inhibits the immunologically induced bronchospasm in guinea pigs[3].
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