(-)-Menthol
CAS No. : 2216-51-5
| Size | Price | Stock |
|---|---|---|
| 100g | $11 | In-stock |
| 500g | $51 | In-stock |
| 1000g | $78 | In-stock |
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| Cat. No. : | HY-75161 |
| M.Wt: | 156.27 |
| Formula: | C10H20O |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic);H2O : 1.89 mg/mL (ultrasonic;warming;heat to 60°C) |
(-)-Menthol is a key component of peppermint oil that binds and activates transient receptor potential melastatin 8 (TRPM8), a Ca2+-permeable nonselective cation channel, to increase [Ca2+]i[1]. Antitumor activity[1].
IC50 & Target:TRPM8[1]
In Vitro: (-)-Menthol (Menthol ) per se does not exhibit antiproliferative activity, but it is able to enhance 1α,25(OH)2D3-mediated growth inhibition in LNCaP cells. At high (-)-Menthol concentrations above 1.6 mM, the cells begin to detach from the culture dish[1].
(-)-Menthol (0.8 mM) can increase [Ca2+]i via transmembrane influx or store release pathways. Peak increase in [Ca2+]i was 102.3±39 nM (n=3) in (-)-Menthol alone and 124.5±51 nM (n=3) in combination of 1α,25(OH)2D3 with (-)-Menthol, respectively[1].
Combination of 1α,25(OH)2D3 with (-)-Menthol (0.8 mM) cooperatively modulates bcl-2 and p21 expression[1].
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