Pinosylvin

Pinosylvin is a?pre-infectious stilbenoid toxin?isolated from the heartwood of Pinus species, has anti-bacterial activities^[1]. Pinosylvin is a resveratrol analogue, can induce cell apoptosis and autophapy in leukemia cells^[2]. In Vitro: Pinosylvin (0-100 μM; 24 hours) is cytotoxic to THP-1 and U937 cells, exhibits an IC₅₀ value of 20-30 μM in leukemia cells, the maximal cytotoxic effect occurred at 100 μM following incubation for 24?hr^[3].
Pinosylvin (0-100 μM; 24 hours) enhances the number of annexin V⁺?and PI⁺?cells in the U937 population at 50 μM, increases annexin V⁺?and PI⁺ cells in the THP-1 population at 100 μM^[3].
Pinosylvin (0-100 μM; 24 hours) promotes autophagy in leukemia cells by enhancing the level of LC3-II and p62/SQSTM1 degradation in leukemia cells^[3].
In Vivo: Pinosylvin (intravenous injection; 10 mg/kg) yields the plasma AUC, urine t , CL and Vd values of 5.23 ± 1.20 mgh mL^-1, 13.13 ± 2.05 h, 1.84 ± 0.44 Lh^-1kg^-1 and 2.29 Lkg^-1, respectively in male Sprague-Dawley rats, in a PK study^[1].