Alclofenac

Alclofenac (Allopydin) is an orally active prostaglandin synthase inhibitor with anti-inflammatory, analgesic and antipyretic activities. Alclofenac irreversibly inhibits platelet aggregation. Alclofenac can be used in research related to rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, low back pain and sciatica^[1]. In Vitro:Alclofenac inhibits prostaglandin biosynthesis in vitro in ram seminal vesicle microsomes^[1].
Alclofenac inhibits oxidative phosphorylation in rat liver mitochondria in vitro^[1].
Alclofenac exerts cytostatic and cytotoxic effects on mammalian cells in vitro^[1].
Alclofenac inhibits collagen- or epinephrine-induced human platelet aggregation in vitro^[1]. In Vivo:Alclofenac (20-100 mg/kg; p.o./s.c.) exhibits dose-dependent anti-inflammatory activity against carrageenan-induced paw edema in rats^[1].
Alclofenac (25-100 mg/kg; p.o./s.c.) prevents and treats adjuvant-induced arthritis in rats^[1].
Alclofenac exhibits analgesic activity in rats^[1].
Alclofenac (100-200 mg/kg; p.o.) exerts a dose-dependent antipyretic effect in febrile rabbits^[1].
Alclofenac (100-200 mg/kg; p.o./i.p.) exerts central nervous system depressant activity in rats, which is manifested by prolonged pentobarbital-induced sleep time^[1].
Alclofenac (10-960 mg/kg; p.o.; once daily; for 5 consecutive days) inhibits acute inflammation in rats in a dose-dependent manner^[2].