1-Naphthyl PP1
CAS No. : 221243-82-9
(Synonyms: 1-NA-PP 1)
| Size | Price | Stock |
|---|---|---|
| 5mg | $90 | In-stock |
| 10mg | $128 | In-stock |
| 25mg | $256 | In-stock |
| 50mg | $410 | In-stock |
| 100mg | $660 | In-stock |
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| Cat. No. : | HY-13941 |
| M.Wt: | 317.39 |
| Formula: | C19H19N5 |
| Purity: | >98 % |
| Solubility: | DMSO : 12.5 mg/mL (ultrasonic) |
1-Naphthyl PP1 (1-NA-PP 1) is a selective inhibitor of src family kinases and Protein Kinase D. 1-Naphthyl PP1 inhibits v-Src and c-Fyn, c-Abl, CDK2 and CAMK II with IC50s of 1.0, 0.6, 0.6, 18 and 22 μM, respectively[1][2][3].
In Vitro:1-Naphthyl PP1 inhibits PKD1, 2, and 3 with IC50s of 154.6 nM, 133.4 nM, 109.4 nM respectively[2].
1-Naphthyl PP1 (0-70 μM, 45 min) inhibits Phorbol 12-myristate 13-acetate (HY-18739) induced autophosphorylation at p-Ser916-PKD1 in LNCaP cells with an IC50 of 22.5 µM[2].
1-Naphthyl PP1 (0-100 μM, 72 h) inhibits PC3 cell proliferation, survival, and arrested cells in G2/M (10 μM, 48 h)[2].
In Vivo:1-Naphthyl PP1 (30 mg/kg, i.p.) reversibly reduces ethanol consumption by ATP analog-specific PKCε (AS-PKCε) mice[3].
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