Antalarmin (hydrochloride)
CAS No. : 220953-69-5
| Size | Price | Stock |
|---|---|---|
| 5mg | $60 | In-stock |
| 10mg | $94 | In-stock |
| 25mg | $188 | In-stock |
| 50mg | $282 | In-stock |
| 100mg | $410 | In-stock |
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| Cat. No. : | HY-103377 |
| M.Wt: | 415.01 |
| Formula: | C24H35ClN4 |
| Purity: | >98 % |
| Solubility: | DMSO : 12.5 mg/mL (ultrasonic;warming);DMF : 20 mg/mL (ultrasonic;warming);Ethanol : 14 mg/mL (ultrasonic;warming) |
Antalarmin (hydrochloride) is an oral active non-peptide corticotropin-releasing hormone receptor 1 (CRHR1) antagonist with a Ki of 1 nM. Antalarmin hydrochloride suppresses CRH-induced ACTH secretion and blocks CRH and novelty induced anxiety-like behavior in animal models. Antalarmin hydrochloride produces anti-inflammatory effects in arthritis models, and suppresses stress-induced gastric ulceration related to irritable bowel syndrome[1][2][3]. In Vitro:Antalarmin (1 µM, 10 minutes) blocks CRH-induced cAMP increase and VEGF production in human mast cells (HMC-1 and hCBMC cells) via CRH-R1[4]. In Vivo:Antalarmin hydrochloride (5, 10, 20 mg/kg, i.p., single dose) blocks CRF-induced anxiety-like behavior and reduces defensive withdrawal in rats[2].
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