EGIS-8332
CAS No. : 220725-87-1
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| Cat. No. : | HY-114975 |
| M.Wt: | 362.38 |
| Formula: | C20H18N4O3 |
| Purity: | >98 % |
| Solubility: |
EGIS-8332 is a non-competitive AMPA receptor antagonist. EGIS-8332 inhibits AMPA currents in rat cerebellar Purkinje cells and inhibited the AMPA- and Quisqualate-induced excitotoxicity in primary cultures of telencephalon neurons (IC50 = 5.1-9.0 μM). EGIS-8332 exhibits anticonvulsant and neuroprotective effects. EGIS-8332 can be used for the research of neurological disease[1].
In Vivo:EGIS-8332 (i.p.) exhibits anticonvulsant effect in maximal electroshock-, sound- and chemically-induced seizures in mice (ED50 = 1.4-14.0 mg kg)[1].
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