MRTX-1257
CAS No. : 2206736-04-9
| Size | Price | Stock |
|---|---|---|
| 5mg | $176 | In-stock |
| 10mg | $264 | In-stock |
| 25mg | $475 | In-stock |
| 50mg | $688 | In-stock |
| 100mg | $998 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-114436 |
| M.Wt: | 565.71 |
| Formula: | C33H39N7O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 55 mg/mL (ultrasonic) |
MRTX-1257 is a selective, irreversible, covalent and orally active KRAS G12C inhibitor, with an IC50 of 900 pM for KRAS dependent ERK phosphorylation in H358 cells[1].
IC50 & Target: IC50: 900 pM (KRAS dependent ERK phosphorylation in H358 cells)[1].
In Vivo: MRTX-1257 (1 mg/kg, 3 mg/kg, 10 mg/kg, 30 mg/kg and 100 mg/kg, orally, daily for 30 days) shows rapid tumor growth inhibition at all dose groups in MIA PaCa-2 G12C Xenograft model in mice[1].
MRTX-1257 shows sustained regression at 3,10, 30, and 100 mg/kg dose groups[1].
MRTX-1257 dosed of 100 mg/kg daily leads to complete responses that are maintained >70 days after cessation of treatment[1].
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