p-MPPI (hydrochloride)


CAS No. : 220643-77-6

220643-77-6
Price and Availability of CAS No. : 220643-77-6
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5mg $64 In-stock
10mg $100 In-stock
25mg $180 In-stock
50mg $300 In-stock
100mg $480 In-stock
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Cat. No. : HY-120738
M.Wt: 578.87
Formula: C25H28ClIN4O2
Purity: >98 %
Solubility: H2O : 3.33 mg/mL (ultrasonic;warming;heat to 60°C);DMSO : 17.86 mg/mL (ultrasonic)
Introduction of 220643-77-6 :

p-MPPI hydrochloride is a selective 5-HT1A receptor antagonist with high affinity for 5-HT1A receptors. p-MPPI hydrochloride can crosses the blood-brain barrier, and has clear antidepressant and anxiolytic-like effects[1][2]. In Vitro: p-MPPI hydrochloride has no agonist activity in both in vitro and in vivo tests of pre- and post-synaptic 5-HT1A receptor activity[1]. In Vivo: p-MPPI hydrochloride (0.5-4.5 mg/kg; i.p.) shows anxiolytic-like profile in the murine elevated plus-maze[2].

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