FzM1.8
CAS No. : 2204290-85-5
| Size | Price | Stock |
|---|---|---|
| 5mg | $66 | In-stock |
| 10mg | $104 | In-stock |
| 25mg | $216 | In-stock |
| 50mg | $356 | In-stock |
| 100mg | $553 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-117163 |
| M.Wt: | 322.31 |
| Formula: | C18H14N2O4 |
| Purity: | >98 % |
| Solubility: | DMSO : 83.33 mg/mL (ultrasonic) |
FzM1.8, derives from FzM1, is an allosteric agonist of FZD4 with pEC50 of 6.4. FzM1.8 binds to FZD4 and activates the WNT/β-catenin pathway, by promoting TCF/LEF transcriptional activity in the absence of any WNT ligand. FzM1.8 stabilizes FZD4 with an increased affinity for heterotrimeric G protein and stimulates the release of the Gβγ subunit that in turn activates PI3K[1]. IC50 & Target:pEC50: 6.4 (FzM1.8)[1]
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