ShK-Dap22
CAS No. : 220384-25-8
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|---|---|---|
| 100μg | $400 | Get quote |
| 500μg | $1000 | Get quote |
| 1mg | $1600 | Get quote |
| 5 mg | Get quote | |
| 10 mg | Get quote | |
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| Cat. No. : | HY-P1274 |
| M.Wt: | 4012.69 |
| Formula: | C166H268N54O48S7 |
| Purity: | >98 % |
| Solubility: | H2O |
ShK-Dap22 is a potent Kv1.3-specific immunosuppressive Polypeptide. ShK-Dap22 is a selective Kv1.3 channel blocker with IC50s of 23 pM, 1.8 nM, 10.5 nM, 37 nM, and 39 nM for mKv1.3, mKv1.1, hKv1.6, mKv1.4, and rKv1.2 channels, respectively[1]. In Vitro: ShK-Dap22 suppresses T cell activation in vitro. ShK-Dap22, at subnanomolar concentrations, suppresses anti-CD3 induced human T-lymphocyte [3H]thymidine incorporation in vitro[1].
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