Cimpuciclib


CAS No. : 2202767-78-8

2202767-78-8
Price and Availability of CAS No. : 2202767-78-8
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Cat. No. : HY-112243
M.Wt: 542.65
Formula: C30H35FN8O
Purity: >98 %
Solubility: 10 mM in DMSO
Introduction of 2202767-78-8 :

Cimpuciclib is a selective CDK4 inhibitor (IC50: 0.49 nM) that has anti-tumor activity[1]. In Vitro:Cimpuciclib (example 63, 141.2 nM, 6 days) inhibits proliferation in colo205 cells[1].
In Vivo:Cimpuciclib (example 63, 50 mg/kg, oral gavage, twice a week) inhibits tumor growth in colo205 tumor-bearing mice[1].
Cimpuciclib (5 mg/kg for rats, 50 mg/kg for colo205 tumor-bearing mice, oral administration) shows slow metabolic rate and maintains high concentration in the plasma[1].

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