AGI-24512
CAS No. : 2201066-53-5
| Size | Price | Stock |
|---|---|---|
| 5mg | $190 | In-stock |
| 10mg | $304 | In-stock |
| 25mg | $495 | In-stock |
| 50mg | $690 | In-stock |
| 100mg | $970 | In-stock |
| 250mg | $1460 | In-stock |
| 500mg | $2100 | In-stock |
| 1g | $2950 | In-stock |
| 5 g | Get quote | |
| 10 g | Get quote | |
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| Cat. No. : | HY-112130 |
| M.Wt: | 400.47 |
| Formula: | C24H24N4O2 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 100 mg/mL |
AGI-24512 is a potent methionine adenosyltransferase 2α (MAT2A) inhibitor, with an IC50 of 8 nM. AGI-24512 triggers DNA damage response. AGI-24512 can block proliferation of MTAP-deleted cancer cells in vitro. AGI-24512 can be used for researching anticancer[1].
IC50 & Target: IC50: 8 nM (MAT2A)[1]
In Vitro: AGI-24512 (0-1 μM; 96 hours) blocks proliferation of MTAP (methylthioadenosine phosphorylase)-deleted HCT116 cancer cells with an IC50 of 100 nM[1].
AGI-24512 significantly increases in γH2AX-positive cells in MTAP-/- HCT116 cells[1].
AGI-24512 inhibits PRMT5-mediated SDMA marks with an IC50 of 95 nM in MTAP-/- cells[1].
AGI-24512 leads to a dose-dependent decrease in SAM (S-adenosylmethionine) levels in the HCT116 MTAP-null cell, with an IC50 of 100 nM[2].
In Vivo: AGI-24512 shows poor oral absorption and a short half-life in rats[2].
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