(R)-Citalopram (oxalate)
CAS No. : 219861-53-7
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| Cat. No. : | HY-110289 |
| M.Wt: | 414.43 |
| Formula: | C22H23FN2O5 |
| Purity: | >98 % |
| Solubility: | DMSO : < 1 mg/mL (ultrasonic;warming;heat to 60°C) |
(R)-Citalopram oxalate, a R-(-) enantiomers of Citalopram (HY-121203), is a serotonin reuptake inhibitor. (R)-Citalopram oxalate is at least 20-fold weaker than S-citalopram (HY-14258) as inhibitor of the 5-HT transporter (SERT). (R)-Citalopram oxalate can be used for research of depression[1][2][3].
In Vitro:(R)-Citalopram (Ki = 330 nM) oxalate is approximately 60 times more weak than S-citalopram (Ki = 5 nM) in Iinhibition of the 5-HT-induced current in hSERT-expressing Xenopus oocytes[2].
R-citalopram oxalate attenuates the S-citalopram-induced inhibition of SERT[2].
In Vivo:(R)-Citalopram (1-7.8 mg/kg; s.c.; single dose) oxalateant's agonistic behaviour appears to be specific for S-citalopram[2].
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