Escitalopram (oxalate)
CAS No. : 219861-08-2
(Synonyms: (S)-Citalopram (oxalate); (S)-(+)-Citalopram (oxalate))
| Size | Price | Stock |
|---|---|---|
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| 10mg | $66 | In-stock |
| 50mg | $92 | In-stock |
| 100mg | $106 | In-stock |
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| Cat. No. : | HY-14258A |
| M.Wt: | 414.43 |
| Formula: | C22H23FN2O5 |
| Purity: | >98 % |
| Solubility: | H2O : ≥ 14.29 mg/mL;DMSO : 116.67 mg/mL (ultrasonic) |
Escitalopram ((S)-Citalopram) oxalate, the S-enantiomer of racemic Citalopram, is a selective serotonin reuptake inhibitor (SSRI) with a Ki of 0.89 nM. Escitalopram oxalate has ∼30 fold higher binding affinity than its R(-)-enantiomer and shows selectivity over both dopamine transporter (DAT) and norepinephrine transporter (NET). Escitalopram oxalate is an antidepressant for the research of major depression[1][2].
IC50 & Target: Ki: 0.89 nM (serotonin transporter), 10500 nM (DAT), 8150 nM (NET)[1]
In Vivo: Escitalopram (10 mg/kg; i.p.; daily for 28 days) ameliorates cognitive impairments and selectively attenuates phosphorylated tau accumulation in stressed rats[3].
Chronic administration of Escitalopram (daily; drinking water for a total of 4 months) significantly reduces plaque load by 28% and 34% at 2.5 and 5 mg/d, respectively [4].
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