7,4'-Dihydroxyflavone
CAS No. : 2196-14-7
| Size | Price | Stock |
|---|---|---|
| 5mg | $35 | In-stock |
| 10mg | $56 | In-stock |
| 25mg | $112 | In-stock |
| 50mg | $180 | In-stock |
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| 200 mg | Get quote | |
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| Cat. No. : | HY-N2609 |
| M.Wt: | 254.24 |
| Formula: | C15H10O4 |
| Purity: | >98 % |
| Solubility: | DMSO : 125 mg/mL (ultrasonic) |
7,4'-Dihydroxyflavone (7,4'-DHF) is a flavonoid, which can be isolated from Glycyrrhiza uralensis. 7,4'-Dihydroxyflavone is eotaxin/CCL11 inhibitor and CBR1 inhibitor (IC50=0.28 μM). 7,4'-Dihydroxyflavone has the ability to consistently suppress eotaxin production and prevent dexamethasone (Dex)‐paradoxical adverse effects on eotaxin production[1]. 7,4'-Dihydroxyflavone (7,4'-DHF) inhibits MUC5AC gene expression, mucus production and secretion via regulation of NF-κB, STAT6 and HDAC2.7,4'-Dihydroxyflavone (7,4'-DHF) decreases phorbol 12-myristate 13-acetate (PMA) stimulated NCI-H292 human airway epithelial cell MUC5AC gene expression and mucus production with IC50 value of 1.4 µM[1].
IC50 & Target:IC50: 1.4 μM (NCI-H292 human airway epithelial cell) (7,4'-Dihydroxyflavone)[1]; 0.28 μM CBR1[2]
In Vitro:7,4'-Dihydroxyflavone (10 μM, 72-120 h) inhibits constitutive eotaxin production in HFL-1 cells[1].
7,4'-Dihydroxyflavone (10 μM, 72 h) decreases IL-4/TNF-α stimulated p-STAT6, p-IκBα, and p-Akt expression in HFL-1 cells[1].
7,4'-Dihydroxyflavone (10 μM, 30 min) inhibits Phorbol 12-myristate 13-acetate (HY-18739) (10 ng/mL for 24 h)-induced MUC5AC production and gene expression in NCI-H292 cells[2].
In Vivo:7,4'-Dihydroxyflavone (6 µg, oral gavage, 4 weeks) inhibits bronchoalveolar lavage (BAL) MUC5AC secretion in a murine asthma model[2].
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