Hydroxyzine (dihydrochloride)
CAS No. : 2192-20-3
| Size | Price | Stock |
|---|---|---|
| 100mg | $60 | In-stock |
| 500mg | $72 | In-stock |
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| Cat. No. : | HY-B0548A |
| M.Wt: | 447.83 |
| Formula: | C21H29Cl3N2O2 |
| Purity: | >98 % |
| Solubility: | H2O : ≥ 150 mg/mL |
Hydroxyzine dihydrochloride, a benzodiazepine antihistamine agent, acts as a orally active histamine?H1-receptor and serotonin antagonist. Hydroxyzine dihydrochloride has anxiolytic effect and can be used forthe research of generalised anxiety disorder[1][2]. In Vitro: Hydroxyzine dihydrochloride inhibits carbachol (10 μM)-induced serotonin release by 34% at 10 μM, by 25% 1 μM and by 17% 0.1 μM in pretreated bladder slices for 60 min[1]. In Vivo: Hydroxyzine dihydrochloride (12.5 mg/kg, 25 mg/kg and 50 mg/kg i.p.) shows little direct analgesic activity but markedly potentiates only the effect of morphine on the vocalization after-discharge which represents the affective component of pain in rats. Hydroxyzine dihydrochloride (50 mg/kg i.p.) potentiates morphine on the tail-flick test, while Hydroxyzine (12.5 mg/kg i.p.) decreases morphine antinociception in rats[3].
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