Taraxerol acetate

Taraxerol acetate is a COX-1 and COX-2 inhibitor with IC₅₀ values of 116.3 μM and 94.7 μM, respectively. Taraxerol acetate the has the anticancer potential and induces cell apoptosis^[1].
In Vitro: Taraxerol acetate(10-150?μM; 24 or 48 hours) induces a dose- and time-dependent cytotoxic effects in the U87 cells, exhibits IC₅₀ values of 34.2 and 28.4?μM, at 24 and 48 h, respectively^[2].
Taraxerol acetate(10, 50 and 150?μM; 24 hours) induces cell apoptosis, the percentage of apoptotic cells increased from 7.3% in the control cells, to 16.1, 44.1 and in the 10, 50 and 150?μM taraxerol acetate-treated cells, respectively. Furthermore, taraxerol acetate treatment led to sub-G1?cell cycle arrest with a corresponding decrease in the number of S-phase cells^[2].