Lycorine (hydrochloride)


CAS No. : 2188-68-3

2188-68-3
Price and Availability of CAS No. : 2188-68-3
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Cat. No. : HY-N0289
M.Wt: 323.77
Formula: C16H18ClNO4
Purity: >98 %
Solubility: DMSO : 25 mg/mL (ultrasonic);H2O : 16.67 mg/mL (ultrasonic)
Introduction of 2188-68-3 :

Lycorine hydrochloride is the main active ingredient of the herbal medicine derived from Lycoris radiata (L’Her.) Herb. and is also a melanoma vasculogenic inhibitor and has anti-tumor activity[1]. Lycorine hydrochloride effectively inhibits mitotic proliferation of Hey1B cells (IC50 of 1.2 μM)[2]. IC50 & Target:IC50: 1.2 μM (Hey1B cells )[2] In Vitro: Lycorine hydrochloride (0-25 μM; 48 hours; C8161 cells) treatment markedly suppresses the expression of vascular endothelial (VE)-cadherin in a dose-dependent manner and also slightly diminishes the expression of Sema4D in C8161 cells. However, the expression of the other six genes is not affected[1].
Lycorine hydrochloride (0-25 μM; 48 hours; C8161 cells) treatment markedly reduces VE-cadherin protein levels in C8161 cells in a dose-dependent fashion[1]. In Vivo: Lycorine hydrochloride (0-15 μg; subcutaneous injection; for 14 days; BALB/C nude mice) treatment has an inhibitory effect on melanoma cell-mediated tumor vasculogenic mimicry[1].

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