IMM-01
CAS No. : 218795-74-5
| Size | Price | Stock |
|---|---|---|
| 5mg | $120 | In-stock |
| 10mg | $210 | In-stock |
| 25mg | $450 | In-stock |
| 50mg | $720 | In-stock |
| 100mg | $1080 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-124808 |
| M.Wt: | 267.35 |
| Formula: | C12H17N3O2S |
| Purity: | >98 % |
| Solubility: | DMSO : 125 mg/mL (ultrasonic) |
IMM-01 is a mammalian Diaphanous (mDia)-related formins agonist that inhibits DID-DAD (diaphanous inhibitory domain-diaphanous autoregulatory domain) binding with an IC50 of 140 nM. IMM-01 acts by disrupting the autoinhibitory bond between the DID and DAD domain and thus activates formins. IMM-01 shows anticancer effects[1].
In Vitro:IMM-01 (100 μM; 1h) induces microtubule stabilization in SW480 colon carcinoma cells[1].
IMM-01 (10 μM) significantly induces LacZ expression in NIH 3T3-SRE-LacZ cells[1].
IMM-01 (1-100 μM; 48 hours) induces caspase-3 cleavage during induction of apoptosis in NIH 3T3 cells and SW480 cells[1].
In Vivo:IMM-01 (5-25 mg/kg; i.v.; 2 times a week; for 3 weeks) is able to slow tumor growth in a mouse xenograft model of colon cancer[1].
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