PPTN trifluoroacetate salt
CAS No. : 2187367-09-3
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| Cat. No. : | HY-110322B |
| M.Wt: | 589.52 |
| Formula: | C31H25F6NO4 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
PPTN trifluoroacetate salt is a potent, high-affinity, competitive and highly selective P2Y14 receptor antagonist with a KB value of 434 pM. Anti-inflammatory and anti-immune activity[1].
IC50 & Target: KB: 434 pM (P2Y14 receptor)[1]
In Vitro: PPTN exhibits strong selectivity for the P2Y14-R over the other seven nucleotide-activated P2Y receptors. 1 μM PPTN exhibits no agonist or antagonist effect at the P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, or P2Y13 receptors[1].
PPTN inhibits UDP-glucose-promoted chemotaxis in differentiated HL-60 human promyelocytic leukemia cells with IC50s of ~1 nM in the presence of 10 μM UDP-glucose and ~4 nM in the presence of 100 μM[1].
PPTN (10 µM) significantly decreases the ratios of p-ERK1/2 to ERK1/2 and p-p38 to p38[2].
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