Bardoxolone (Standard)


CAS No. : 218600-44-3

(Synonyms: CDDO (Standard); RTA 401 (Standard))

218600-44-3
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Cat. No. : HY-14909R
M.Wt: 491.66
Formula: C31H41NO4
Purity: >98 %
Solubility:
Introduction of 218600-44-3 :

Bardoxolone (Standard) is the analytical standard of Bardoxolone (HY-14909). This product is intended for research and analytical applications. Bardoxolone is an orally active activator of nuclear regulatory factor (NRf-2) and an inhibitor of SARS-CoV-2 3CL protease. Bardoxolone inhibits SARS-CoV-2 3CL protease with an EC50 value of 0.43 μM in vero cells. Bardoxolone also inhibits necroptosis in HT-29 cells with an EC50 value of 1.30 μM by blocking necrosome formation through inhibiting phosphorylation of RIPK1 and RIPK3. Bardoxolone can be used in research on COVID-19, TNF-induced systemic inflammatory response syndrome (SIRS), and cerebral ischemia-reperfusion injury[1][2]. IC50 & Target:Nrf-2[1]

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