5α-Pregnane-3β,6α-diol-20-one
CAS No. : 21853-11-2
| Size | Price | Stock |
|---|---|---|
| 5mg | $120 | In-stock |
| 10mg | $208 | In-stock |
| 50mg | $576 | In-stock |
| 100mg | $807 | In-stock |
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| Cat. No. : | HY-109564 |
| M.Wt: | 334.49 |
| Formula: | C21H34O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
5α-Pregnane-3β,6α-diol-20-one is a mitogenic metabolite of progesterone, and it can be produced in starved androgen-responsive prostate cancer cells. In Vitro: Progesterone is converted to 5α-pregnane-3β,6α-diol-20-one in human fibroblasts[1]. Pregnenolone and progesterone are avidly metabolized to 5α-pregnan-3β,6α-diol-20-one in the C4.2 cell line, with nearly complete conversions at 24 h and 18 h, respectively. Preferential 5α-pregnan-3β,6α-diol-20-one formation from early steroid precursors is independent of CYP17A1 but rather relies on 3β-HSD activity[2].
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