RPR-200765A (methanesulfonate)
CAS No. : 218162-38-0
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| Cat. No. : | HY-123670 |
| M.Wt: | 548.58 |
| Formula: | C25H29FN4O7S |
| Purity: | >98 % |
| Solubility: |
RPR-200765A methanesulfonate is an orally active p38 MAPK inhibitor with an IC50 of 0.050 μM. RPR-200765A methanesulfonate shows weak activity against Lck, and exhibits no significant activity against ERK, ZAP70 or SYK. It inhibits the production of TNFα and can be used in the research of inflammatory diseases[1].
In Vitro:RPR-200765A methanesulfonate potently inhibits p38 kinase with an IC50 of 0.050 μM, and exhibits weak or no inhibition of ERK, ZAP70, SYK, and Lck kinases[1].
RPR-200765A methanesulfonate is non-mutagenic in the Ames test and CHO cell micronucleus test, and does not induce CYP1A1 in rat hepatocytes[1].
In Vivo:RPR-200765A methanesulfonate (6 mg/kg; p.o.; single administration) inhibits LPS (HY-D1056)-induced TNFα release in mice, with an oral ED50 of 6 mg/kg[1].
RPR-200765A methanesulfonate (3-30 mg/kg; p.o.; twice daily for 28 days) reduces paw swelling in adjuvant-induced arthritis rats in a dose-dependent manner[1].
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