SRPIN340
CAS No. : 218156-96-8
(Synonyms: SRPK inhibitor)
| Size | Price | Stock |
|---|---|---|
| 5mg | $79 | In-stock |
| 10mg | $132 | In-stock |
| 25mg | $280 | In-stock |
| 50mg | $449 | In-stock |
| 100mg | $581 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-13949 |
| M.Wt: | 349.35 |
| Formula: | C18H18F3N3O |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 42 mg/mL |
SRPIN340 is an ATP-competitive serine-arginine-rich protein kinase (SRPK) inhibitor, with a Ki of 0.89 μM for SRPK1. IC50 & Target:Ki: 0.89 μM (SRPK1)[1] In Vitro: SRPIN340 is a serine-arginine-rich protein kinase (SRPK) inhibitor, with a Ki of 0.89 μM for SRPK1. SRPIN340 also inhibits SRPK2, but shows no significant inhibition on other SRPK, such as Clk1 and Clk4. SRPIN340 promotes degradation of SRp75, which is necessary for HIV expression. SRPIN340 suppresses the propagation of Sindbis virus (IC50, 60 μM) as well as severe acute respiratory syndrome virus[1]. SRPIN340 shows inhibitory effect on leukemia cell lines, such as AML HL60, ALL-T Molt4 and Jurkat, with IC50s of 44.7 μM, 92.2 μM and 82.3 μM, respectively[2].
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