Diallyl disulfide
CAS No. : 2179-57-9
| Size | Price | Stock |
|---|---|---|
| 5g | $7 | In-stock |
| 25g | $17 | In-stock |
| 100g | $60 | In-stock |
| 500g | $180 | In-stock |
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| Cat. No. : | HY-W015635 |
| M.Wt: | 146.27 |
| Formula: | C6H10S2 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Diallyl disulfide, an active compound in garlic oil, is an orally active human squalene monooxygenase inhibitor with an IC50 of 400 μM for squalene epoxidation. Diallyl disulfide exhibits obvious anti-inflammatory, anti-oxidative, antidepressant and anti-tumor activities[1][2][3][4].
In Vitro:Diallyl disulfide (30, 60, 120, 240 μM; 12, 24, 48 h) suppresses HT-29 cell growth[2].
Diallyl disulfide (30, 60, 120 μM; 24 h) induces cell cycle arrest in the G2/M-phase in HT-29 cells in a concentration-independent manner[2].
Diallyl disulfide (120 μM) induces the mRNA levels of ARPC3, SPINT2, SOD1, p21 and TACSTD2[2].
In Vivo:Diallyl disulfide (40, 80 mg/kg; IP; pre-treatment 1 h) has a prophylactic effect in LPS-induced depression-like behaviors in mice[3].
Diallyl disulfide (30, 60, 90 mg/kg; oral gavage; three times/week for the last 30 days) dose-dependently reduces cigarette smoke (CS) -induced leukocyte infiltration into the airways and improves lung histology in C57BL/6 mice were exposed to CS for 60 consecutive days[4].
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