Benzcyclane
CAS No. : 2179-37-5
(Synonyms: Bencyclane; Benzcyclan)
| Size | Price | Stock |
|---|---|---|
| 5mg | $350 | In-stock |
| 10mg | $560 | In-stock |
| 25mg | $950 | In-stock |
| 50mg | $1350 | In-stock |
| 100mg | $1760 | In-stock |
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| Cat. No. : | HY-U00134 |
| M.Wt: | 289.46 |
| Formula: | C19H31NO |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 100 mg/mL |
Benzcyclane (Bencyclane; Benzcyclan) is a serotonin receptor antagonist and a cerebral/peripheral vasodilator. Benzcyclane exerts atypical serotonin antagonistic effects in rabbit superior mesenteric arteries. Benzcyclane relaxes high K+-induced contractions in rabbit basilar arteries and superior mesenteric arteries, and selectively inhibits sympathetic nerve stimulation-induced contractions in rabbit pulmonary arteries. Benzcyclane exerts non-competitive norepinephrine antagonistic effects in rabbit superior mesenteric arteries, and slightly reduces the maximum contractile response induced by histamine. Benzcyclane relaxes smooth muscles, induces transient hypotension, inhibits thrombosis, and accelerates blood fibrinolytic activity. Benzcyclane increases cerebral glucose content/uptake, enhances hypoxia tolerance in mice, and increases cerebral blood supply in dogs. Benzcyclane is applicable to studies related to cerebral vascular circulation[1].
In Vitro:Benzcyclane (0.0001-0.03 mg/mL; 2-3 minutes per concentration, 10-20 minutes for maximum relaxation) potently relaxes high K+-induced contractures in isolated rabbit basilar artery strips with an ED50 of 0.0011 mg/mL, producing faster and more marked relaxation than in mesenteric artery strips[1].
Benzcyclane (~30 minutes for maximum relaxation) relaxes high K+-induced contractures in isolated rabbit superior mesenteric artery strips with an ED50 of 0.0048 mg/mL, showing weaker and slower relaxation than in basilar artery strips[1].
Benzcyclane exerts the strongest antagonistic effect on serotonin-induced contractions in isolated rabbit superior mesenteric artery strips (presumptive pA2 = 7.3), with weaker noncompetitive antagonism of noradrenaline (pD2' = 4.3) and minimal effect on histamine (pD2' = 3.8)[1].
Benzcyclane (0.006 mg/mL, 0.01 mg/mL; 30 minutes for nerve stimulation, 20 minutes for noradrenaline) selectively inhibits 25 Hz sympathetic nerve-induced contractions in isolated rabbit pulmonary artery radial muscle preparations without affecting responses to exogenous noradrenaline[1].
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