TLR7 agonist 1
CAS No. : 2178156-33-5
| Size | Price | Stock |
|---|---|---|
| 5mg | $350 | In-stock |
| 10mg | $600 | In-stock |
| 25mg | $1250 | In-stock |
| 50mg | $1950 | In-stock |
| 100mg | $3200 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-111358 |
| M.Wt: | 363.46 |
| Formula: | C21H25N5O |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 100 mg/mL |
TLR7 agonist 1 is a selective TLR7 agonist with an LEC value of 90 nM. TLR7 agonist 1 activates downstream immune regulation and shows no activity against TLR8. TLR7 agonist 1 induces endogenous IFN-α production in mice[1].
IC50 & Target:IC50: 90 nM (TLR7)[1]
In Vitro:TLR7 agonist 1 (compound 48) (0.09 μM) is a highly potent, TLR7-selective agonist (SI >200 over TLR8) in HEK-293 cells transiently transfected with human TLR7, with an hTLR7 LEC of 0.09 μM[1].
TLR7 agonist 1 (0.14 μM) induces IFN-α in hPBMCs with an LEC50 of 0.14 μM[1].
TLR7 agonist 1 (>25 μM) has low cytotoxicity in HEK-293 cells[1].
TLR7 agonist 1 (1 μM; 15 min) exhibits moderate metabolic stability in human liver microsomes[1].
TLR7 agonist 1 (10 μM) shows no CYP inhibition up to 10 μM in human liver microsomes[1].
In Vivo:TLR7 agonist 1 (compound 48) (5 mg/kg; p.o.; single dose) induces a peak plasma mIFN-α level of 2800 pg/mL at 4 hours in healthy C57BL/6 mice, with higher liver exposure than systemic exposure[1].
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